Improved limits of detection with electrochemical detection

Improved limits of detection with electrochemical detection

Sometimes size does matter.

Pulsed amperometric detectors

Due to matrix complications, detection limit requirements and standard methods, pulsed amperometric detectors, PADs, are common feature of ion chromatography in the pharmaceutical laboratory.

A key benefit of the PAD is its selective nature. Along with the expected chromatography variations in columns and mobile phases, the PAD provides a range of possible variations in setup to ensure accurate analysis.

One example is the working electrode. Various materials are used to improve detection limits and working life of electrodes under optimum conditions. Examples of electrode/application pairings are listed below.

Typical application of the different working electrodes

Working electrodes


  • Mono-, di-, oligo- and polysaccharides, sugar alcohols, sugar amines, sugar acids
  • Amino acids
  • Antibiotics
  • Halogen anions, e.g. bromide, iodide
  • Cyanide and sulfide
  • Thiosulfate
  • Pharmaceuticals
  • Alcohols and glycols
  • Hydrazines
  • Arsenite and hypochlorite
  • Inorganic anions, e.g. nitrite,  sulfite, iodide
  • Phenols
  • Catecholamines and aromatic amines
  • Vitamins

Ask us how you can lower your detection limits, and electrode costs.

Questions? Contact us
Metrohm Australia/New Zealand

Please select your topic:

Please select your field of practice:*

Your message:* (required)

Please enter

Your email address*

Title: MrMrsMsDrProf

First Name*:

Last Name*:







Phone Number:

Would you like to subscribe to one or more of our regular scientific publications?

Air Water Soil (email)Chemical and Petrochemical Analysis (email)ElectroChem Matters (email)FoodLab and Beverage Analysis (email)Ion Chromatography News (email)Metrohm Australia Analyst (email)Metrohm Australia Analyst (print)Metrohm Information (print)Mines&Minerals (email)Process Analytics (email)Retsch the Sample (print)Solid Science (email)Teaching and Research (email)

Please enter the displayed code:


Manage your subscriptions


This site is up and running - except for the store and online payment area. Thank you. Dismiss