Improved limits of detection with electrochemical detection

Improved limits of detection with electrochemical detection

Sometimes size does matter.

Pulsed amperometric detectors

Due to matrix complications, detection limit requirements and standard methods, pulsed amperometric detectors, PADs, are common feature of ion chromatography in the pharmaceutical laboratory.

A key benefit of the PAD is its selective nature. Along with the expected chromatography variations in columns and mobile phases, the PAD provides a range of possible variations in setup to ensure accurate analysis.

One example is the working electrode. Various materials are used to improve detection limits and working life of electrodes under optimum conditions. Examples of electrode/application pairings are listed below.

Typical application of the different working electrodes

Working electrodes

Application

Au
  • Mono-, di-, oligo- and polysaccharides, sugar alcohols, sugar amines, sugar acids
  • Amino acids
  • Antibiotics
Ag
  • Halogen anions, e.g. bromide, iodide
  • Cyanide and sulfide
  • Thiosulfate
  • Pharmaceuticals
Pt
  • Alcohols and glycols
  • Hydrazines
  • Arsenite and hypochlorite
GC
  • Inorganic anions, e.g. nitrite,  sulfite, iodide
  • Phenols
  • Catecholamines and aromatic amines
  • Vitamins

Ask us how you can lower your detection limits, and electrode costs.

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