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Content uniformity of pharmaceutical solid dosage forms using Vis-NIR spectroscopy

Content uniformity of pharmaceutical solid dosage forms using Vis-NIR spectroscopy

Vis-NIR analytical technique enables significant cost and time savings compared to standard reference analysis. Pharmaceutical quality control is an indispensable part of the pharmaceutical manufacturing process. One of the key quality parameters that has to be determined is the uniformity of dosage units. The pharmaceutical manufacturer has to ensure the...
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Karl Fischer Titration, accurate moisture analysis

Karl Fischer Titration, accurate moisture analysis

Metrohm offers monographs, webinars, application notes and simple tips and tricks for optimising Karl Fischer analysis – and a full range of leading KF instruments. Pharmaceuticals require control of all components in the manufacturing process. The most common component to all manufacturing is water. As moisture analysis is so heavily...
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White Paper: Surface Enhanced Raman Scattering (SERS) – Expanding the Limits of Conventional Raman Analysis

White Paper: Expanding the limits of conventional Raman analysis with SERS

The advantage of SERS for the analytical chemist lies in its ability to detect analyte concentrations of parts per million and even parts per billion levels, while classical Raman is limited to parts per thousand. Surface Enhanced Raman Scattering (SERS) – Expanding the limits of conventional Raman analysis Methods for...
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Change the way you use your Mass Spectrometer

Change the way you use your Mass Spectrometer

Improve the analytical range of your MS and ICP/MS with an IC for speciation Mass spectrometers and ICP/MS instruments provide trace level analysis of a wide range of metals and components. The limitation of these techniques arrives when analysing oxidation states of metals or compounds. The addition of ion chromatography...
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Lower the costs of etching bath control

Lower the costs of etching bath control

Improve performance while lowering costs with Metrohm Process Ion Chromatographs The analysis of samples from an etching baths can provide an analytical challenge. This is due to the varying pH and high levels of metals make direct Ion Chromatography impossible. While Ion Chromatography is perfect for the analysis of acids...
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Manganese in drinking water

Manganese in drinking water

Manganese (Mn) is an element that can impart undesirable taste and odour in drinking water. Mn also contributes to discoloured water that may result in dirty or stained clothes during washing. To ensure that the drinking water fulfils desired target, having the online analyser is essential. The method of choice...
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Shutdown procedures

Shutdown procedures for ion chromatographs

Going away for the holidays? Make sure your IC will be read for you when you get back. Everyone needs a holiday. Shutdown procedures when on holidays For some laboratories that means the instruments get a break too. While some instruments require continuous operation to be ready when you get...
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Partial Loop Injection

Partial Loop Injection (Ion Chromatography)

Increase the flexibility of your IC. Analytical instruments are designed to run with sample concentrations in optimal windows and preferred matrices. Unfortunately, not all samples are created equal. If you have samples from a range of sources, you are likely to have concentrations and matrices over a wide range too....
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Ensuring accuracy in IC analysis

Ensuring accuracy in IC analysis

Prove your system is giving you the right results, beyond a doubt. How often do I need to calibrate my instrument? How do I know the results are accurate? These are questions we often hear when visiting customers new to using Ion Chromatography, and they are valid questions too. Using...
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NIR performs better with homogenous size reduction

NIR performs better with homogenous size reduction

Near Infrared Spectroscopy is the most important analysis method for the determination of protein content, moisture, fat and ash in feeds and forage. The advantage over classical methods such as Kjeldahl is the simultaneous determination of several parameters. Moreover, NIR spectroscopy is a quick method which neither requires consumables nor...
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Why size reduction? The influence on standard deviation

Why size reduction? The influence on standard deviation

A reliable and accurate analysis can only be guaranteed by reproducible sample preparation. The "Art of Milling" describes the process of turning a laboratory sample into a representative part sample with homogeneous analytical fineness. For this task RETSCH offers a comprehensive range of the most modern laboratory mills and crushers...
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Screen-Printed Electrodes for Uric Acid Detection

Screen-printed electrodes for uric acid detection

Amperometric Detection of uric acid (UA) in 20mM sodium Borate buffer pH 8. Edet= -0.1V. Screen-printed electrodes for uric acid detection Uric acid is the major end product of purine metabolism. It is present in biological fluids such as urine and blood serum and the detection of anomalous values can...
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