Category

Pharma and Nutraceuticals
Surfactants Analysis and Pharmaceuticals

Surfactants analysis and pharmaceuticals

Which titration suits your requirements best? Surfactant analysis does not follow the standard titration application profile. Anionic surfactant, cation surfactant, non-ionic surfactant, dual-phase titration; each has it’s own intricacy and fine-tuning. It is enough to make your head spin. Where do you start for the best analysis method? How do...
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Quantification of USP heparin units using near-infrared spectroscopy

Quantification of USP heparin units using near-infrared spectroscopy

Correlation plot of the predicted Heparin sodium product strength by NIRS versus the laboratory values. Displayed are the training data (blue) and validation data (turquois). Heparin is a glycosaminoglycan used as an anticoagulant for therapeutic uses. It can either be used directly for humans given by injection or used as...
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High standards require the most accurate analysis

High standards require the most accurate analysis

High standards require the most accurate analysis.  That’s where DIA stands apart from other techniques! Higher resolution, better sensitivity, and excellent reproducibility: this is how Dynamic Image Analysis (DIA) improves the characterisation of powders and granulates in both quality control and R&D. This white paper outlines how particle size distribution...
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Monitoring the purity of recovered solvents with NIRS

Monitoring the purity of recovered solvents with NIRS

The purity of a solvent (dichloromethane/methylene chloride) is monitored by NIR spectroscopy along with two of the major impurities (methanol and water). Recovering solvents The solvents that are used in manufacturing processes are often not disposed of or incinerated, but instead recovered and purified, as this saves considerable costs. Distillation...
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Improved limits of detection with electrochemical detection

Improved limits of detection with electrochemical detection

Sometimes size does matter. Due to matrix complications, detection limit requirements and standard methods, pulsed ammperometric detectors, PADs, are common feature of ion chromatography in the pharmaceutical laboratory. A key benefit of the PAD is its selective nature. Along with the expected chromatography variations in columns and mobile phases, the...
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Non-aqueous titrations

Non-aqueous titrations, simplified

Cleaning electrodes getting you down? Relax, the Solvotrode easyClean is here to help. Non-aqueous titrations have a habit of producing gluggy, gelatinous messes that take forever to clean from an electrode. For regular non-aqueous electrodes this means blocked membranes and low electrolyte flow, which in turn leads to slow responses,...
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Moisture in a lyophilized pharmaceutical by near-infrared spectroscopy

Moisture in lyophilized pharmaceuticals by near-infrared spectroscopy

Metrohm near-infrared spectrometer in diffuse reflection mode is ideal for determining the residual moisture in a lyophilized pharmaceutical product. Analysis of residual moisture in a lyophilised pharmaceutical product by near-infrared spectroscopy (NIRS) Quantification of residual moisture in lyophilised parenteral products is an important measurement in the pharmaceutical industry. Analyses are...
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Metrohm Moisture Plus: Multi-parameter analysis in seconds

Metrohm’s Moisture Plus near-infrared (NIR) spectroscopy changes the way you do moisture analysis. It combines Karl Fischer titration, the gold standard for moisture analysis, with other analyses for different chemical and physical parameters into a single NIR measurement. This approach increases speed and lowers overall measurement costs. Most companies see...
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Need Ion Chromatographic analysis but you don’t want a new software? Metrohm IC operates with Empower too

Need ion chromatographic analysis but you don’t want a new software? Metrohm IC operates with Empower, too!

Software validations are long and tedious for everyone involved. Utilising a central software to control instrument and log data can save days of validation time, if not longer. For the pharmaceutical industry, LC and HPLC analysis is prevalent, making it logical to focus on a single software platform for instrument...
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All of your audit requirements at your fingertips

All of your audit requirements at your fingertips

Metrohm titration software provides all of the software compliance requirements are included! Password monitoring, user administration, data backup and audit trail monitoring are all incorporated into Tiamo software for Karl Fischer Moisture, Potentiometric Titration, pH and Ion Selective measurement.
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Analysis of active constituents in medicinal plants

Analysis of active constituents in medicinal plants

Qualitative and quantitative analysis of active constituents in medicinal plants.  A cost effective solution for the nutraceutical industry Near-infrared (NIR) spectroscopy is a technique accepted in the United States, European and Japanese Pharmacopeia and has been successfully used for ingredient identification and quantification in the pharmaceutical and nutraceutical industry for...
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Control dry granulation with ease and reliability (Pharma)

Control dry granulation with ease and reliability

Pharmaceutical dry granulation Pharmaceutical granules are, from a technical point of view, agglomerates that usually consist of a mixture of a medicinal agent and various excipients. The granules can be prepared by different methods. One of these is dry granulation, a simple and rapid method. Mixtures of powders containing the...
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