Category

Pharma and Nutraceuticals
Content uniformity of pharmaceutical solid dosage forms using Vis-NIR spectroscopy

Content uniformity of pharmaceutical solid dosage forms using Vis-NIR spectroscopy

Vis-NIR analytical technique enables significant cost and time savings compared to standard reference analysis. Pharmaceutical quality control is an indispensable part of the pharmaceutical manufacturing process. One of the key quality parameters that has to be determined is the uniformity of dosage units. The pharmaceutical manufacturer has to ensure the...
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More convenient and more reliable: USP recommends new ion chromatography method for zinc oxide assay

More convenient and more reliable: USP recommends new ion chromatography method for zinc oxide assay

Zinc oxide is used in various skin care creams, drugs, and drug products. «Zinc Determination» monograph includes ion chromatography USP has updated the General Chapter <591> «Zinc Determination» monograph to include ion chromatography as the preferred method for measuring zinc oxide. USP 41–NF 36 was developed in partnership with Metrohm...
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The new Mira P for the pharmaceutical industry: Instant onsite verification of raw materials

The new Mira P for the pharmaceutical industry: Instant onsite verification of raw materials

The Mira P is fast, easy, and accurate helping users optimize the inspection of incoming goods, formulation verification, and process monitoring. Mira P for the pharmaceutical industry: Instant onsite verification of raw materials Metrohm is introducing the latest compliant handheld Raman solution for the pharmaceutical industry. Mira P offers enhanced...
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Surfactants Analysis and Pharmaceuticals

Surfactants analysis and pharmaceuticals

Which titration suits your requirements best? Surfactant analysis does not follow the standard titration application profile. Anionic surfactant, cation surfactant, non-ionic surfactant, dual-phase titration; each has it’s own intricacy and fine-tuning. It is enough to make your head spin. Where do you start for the best analysis method? How do...
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Quantification of USP heparin units using near-infrared spectroscopy

Quantification of USP heparin units using near-infrared spectroscopy

Correlation plot of the predicted Heparin sodium product strength by NIRS versus the laboratory values. Displayed are the training data (blue) and validation data (turquois). Heparin is a glycosaminoglycan used as an anticoagulant for therapeutic uses. It can either be used directly for humans given by injection or used as...
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High standards require the most accurate analysis

High standards require the most accurate analysis

High standards require the most accurate analysis.  That’s where DIA stands apart from other techniques! Higher resolution, better sensitivity, and excellent reproducibility: this is how Dynamic Image Analysis (DIA) improves the characterisation of powders and granulates in both quality control and R&D. This white paper outlines how particle size distribution...
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Monitoring the purity of recovered solvents with NIRS

Monitoring the purity of recovered solvents with NIRS

The purity of a solvent (dichloromethane/methylene chloride) is monitored by NIR spectroscopy along with two of the major impurities (methanol and water). Recovering solvents The solvents that are used in manufacturing processes are often not disposed of or incinerated, but instead recovered and purified, as this saves considerable costs. Distillation...
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Improved limits of detection with electrochemical detection

Improved limits of detection with electrochemical detection

Sometimes size does matter. Due to matrix complications, detection limit requirements and standard methods, pulsed ammperometric detectors, PADs, are common feature of ion chromatography in the pharmaceutical laboratory. A key benefit of the PAD is its selective nature. Along with the expected chromatography variations in columns and mobile phases, the...
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Non-aqueous titrations

Non-aqueous titrations, simplified

Cleaning electrodes getting you down? Relax, the Solvotrode easyClean is here to help. Non-aqueous titrations have a habit of producing gluggy, gelatinous messes that take forever to clean from an electrode. For regular non-aqueous electrodes this means blocked membranes and low electrolyte flow, which in turn leads to slow responses,...
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Moisture in a lyophilized pharmaceutical by near-infrared spectroscopy

Moisture in lyophilized pharmaceuticals by near-infrared spectroscopy

Metrohm near-infrared spectrometer in diffuse reflection mode is ideal for determining the residual moisture in a lyophilized pharmaceutical product. Analysis of residual moisture in a lyophilised pharmaceutical product by near-infrared spectroscopy (NIRS) Quantification of residual moisture in lyophilised parenteral products is an important measurement in the pharmaceutical industry. Analyses are...
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Metrohm Moisture Plus: Multi-parameter analysis in seconds

Metrohm’s Moisture Plus near-infrared (NIR) spectroscopy changes the way you do moisture analysis. It combines Karl Fischer titration, the gold standard for moisture analysis, with other analyses for different chemical and physical parameters into a single NIR measurement. This approach increases speed and lowers overall measurement costs. Most companies see...
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Need Ion Chromatographic analysis but you don’t want a new software? Metrohm IC operates with Empower too

Need ion chromatographic analysis but you don’t want a new software? Metrohm IC operates with Empower, too!

Software validations are long and tedious for everyone involved. Utilising a central software to control instrument and log data can save days of validation time, if not longer. For the pharmaceutical industry, LC and HPLC analysis is prevalent, making it logical to focus on a single software platform for instrument...
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